Isoniazid Injection and Parafon Forte DSC
Determining the interaction of Isoniazid Injection and Parafon Forte DSC and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using chlorzoxazone together with isoniazid may increase the effects of chlorzoxazone. Contact your doctor if you experience headache, nausea, or drowsiness. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: In one small study, patients receiving isoniazid were reported to have a 44% increased peak concentration of chlorzoxazone, 125% increased area under the plasma concentration-time curve, and 99% prolonged mean plasma elimination half-life. The oral clearance of chlorzoxazone was reported to have been reduced. Chlorzoxazone is a substrate of CYP2E1. Isoniazid is an inducer and inhibitor of CPY2E1.
MANAGEMENT: Caution is advised for increased levels of chlorzoxazone if these medications are to be used together. Dosage adjustments may be appropriate. Patients should be advised to notify their physician if they experience headache, nausea, or drowsiness.
- Leclercq I, Desager JP, Horsmans Y "Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestion of watercress." Clin Pharmacol Ther 64 (1998): 144-9
Generic Name: isoniazid
Brand name: Nydrazid
Synonyms: Isoniazid
Generic Name: chlorzoxazone
Brand name: Lorzone, Parafon Forte DSC, Paraflex, Remular-S, Relaxazone, Eze DS, Remular, Strifon Fort
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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