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Lanoxin (Digoxin Injection) and Sucralfate Tablets

Determining the interaction of Lanoxin (Digoxin Injection) and Sucralfate Tablets and the possibility of their joint administration.

Check result:
Lanoxin (Digoxin Injection) <> Sucralfate Tablets
Relevance: 06.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using sucralfate together with digoxin may decrease the effects of digoxin. Digoxin should be administered at least two hours before or 6 hours after sucralfate. Contact your doctor if you experience worsening of heart symptoms. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Sucralfate may reduce the therapeutic effect of digitalis glycosides by interfering with their absorption.

MANAGEMENT: Digitalis should be administered at least two hours before or 6 hours after sucralfate. Patients should be advised to notify their doctor if they experience worsening of their heart symptoms.

References
  • McCarthy DM "Sucralfate." N Engl J Med 325 (1991): 1017-25
  • "Product Information. Carafate (sucralfate)." Hoechst Marion-Roussel Inc, Kansas City, MO.
  • Rey AM, Gums JG "Altered absorption of digoxin, sustained-release quinidine, and warfarin with sucralfate administration." DICP 25 (1991): 745-6
Lanoxin (Digoxin Injection)

Generic Name: digoxin

Brand name: Lanoxin, Digitek, Digox, Lanoxicaps, Cardoxin

Synonyms: Lanoxin

Sucralfate Tablets

Generic Name: sucralfate

Brand name: Carafate

Synonyms: Sucralfate

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle