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Lopid and Neoral

Determining the interaction of Lopid and Neoral and the possibility of their joint administration.

Check result:

Lopid <> Neoral

Relevance: 13.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using gemfibrozil together with cycloSPORINE may decrease the effects of cycloSPORINE. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Gemfibrozil when used concomitantly with cyclosporine may lead to decreased cyclosporine trough levels and subsequent reduction in effectiveness of the immunosuppressant. The mechanism of the interaction is unknown.
MANAGEMENT: Monitoring of cyclosporine concentrations and clinically observing the patient for signs of organ rejection is recommended.

References

Fehrman-Ekholm I, Jogestrand T, Anelin B "Decreased cyclosporine levels during gemfibrozil treatment of hyperlipidemia after kidney transplantation." Nephron 72 (1996): 483

Lopid

Generic Name: gemfibrozil

Brand name: Lopid

Synonyms: n.a.

What is Lopid?

Neoral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Neoral (Capsules, Modified)

What is Neoral?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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