Metformin and sitagliptin and Neoral
Determining the interaction of Metformin and sitagliptin and Neoral and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with cyclosporine, a potent inhibitor of P-glycoprotein efflux transporter, does not appear to significantly alter the pharmacokinetics of sitagliptin, which is a substrate of P-glycoprotein. Following coadministration of a single 100 mg oral dose of sitagliptin and a single 600 mg oral dose of cyclosporine, the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of sitagliptin were increased by 68% and 29%, respectively. These changes are not considered clinically significant. The renal clearance of sitagliptin was also not significantly altered in the presence of cyclosporine.
- "Product Information. Januvia (sitagliptin)." Merck & Company Inc, West Point, PA.
Generic Name: metformin / sitagliptin
Brand name: Janumet, Janumet XR
Synonyms: Sitagliptin and Metformin
Generic Name: cyclosporine
Brand name: Gengraf, Neoral, Sandimmune, Sandimmune
Synonyms: Neoral (Capsules, Modified)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Metformin and sitagliptin-Neoral (Cyclosporine Capsules, Modified)
- Metformin and sitagliptin-Neoral (Cyclosporine Oral Solution, Modified)
- Metformin and sitagliptin-Neoral Oral
- Metformin and sitagliptin-Neosar
- Metformin and sitagliptin-Neosporin + Pain Relief Ointment
- Metformin and sitagliptin-Neosporin AF Topical
- Neoral-Metformin Extended-Release Tablets
- Neoral-Metformin Hydrochloride
- Neoral-Metformin Oral Solution
- Neoral-Metformin Tablets
- Neoral-Methacholine
- Neoral-Methadone