Paricalcitol Injection and PCE Dispertab

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Erythromycin may increase the blood levels of paricalcitol. Contact your doctor if you experience increased side effects or if your condition worsens. Blood calcium and phosphorous levels should be monitored. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with potent inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of paricalcitol, which is partially metabolized by the isoenzyme. According to product labeling, pretreatment with the potent CYP450 3A4 inhibitor ketoconazole (200 mg twice daily for 5 days) in healthy volunteers approximately doubled the area under the plasma concentration-time curve (AUC) and half-life of paricalcitol (administered in a capsule formulation) compared to administration of paricalcitol alone.

MANAGEMENT: Caution is advised when paricalcitol is used with potent CYP450 3A4 inhibitors. Serum calcium and phosphorus levels should be monitored closely. If clinically significant hypercalcemia develops, the paricalcitol dose should be reduced or interrupted and support therapy administered.

Paricalcitol Injection

Generic Name: paricalcitol

Brand name: Zemplar

Synonyms: Paricalcitol

What is Paricalcitol Injection?

PCE Dispertab

Generic Name: erythromycin

Brand name: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

Synonyms: PCE Dispertab (Oral), PCE, PCE (Oral)

What is PCE Dispertab?