Raltegravir Powder for Oral Suspension and Sustiva
Determining the interaction of Raltegravir Powder for Oral Suspension and Sustiva and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with efavirenz may reduce the plasma concentrations of raltegravir. The mechanism of interaction has not been described. In 9 study subjects administered a single 400 mg dose of raltegravir in combination with efavirenz 600 mg daily, raltegravir peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) decreased by 36%, 36% and 21%, respectively, compared to administration of raltegravir alone. These changes were statistically, but not clinically, significant. Raltegravir and efavirenz may be coadministered without any dosage adjustments.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Isentress (raltegravir)." Merck & Company Inc, West Point, PA.
Generic Name: raltegravir
Brand name: Isentress, Isentress HD
Synonyms: Raltegravir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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