Rifabutin and Vfend

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using rifabutin and voriconazole is not recommended. Call your doctor if you notice that voriconazole is not working or if your infection worsens. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration with rifabutin may significantly reduce the plasma concentrations of voriconazole. The mechanism is rifabutin induction of CYP450 isoenzymes that are responsible for the metabolic clearance of voriconazole. According to the manufacturer, rifabutin (300 mg once daily) decreased the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of voriconazole (200 mg every 12 hours) by an average of 67% and 79%, respectively, in healthy subjects. Doubling the dose of voriconazole with the same dosage of rifabutin resulted in Cmax and AUC that were on average approximately 2 times higher compared with voriconazole alone at 200 mg twice daily. Coadministration of voriconazole at 400 mg twice daily with rifabutin at 300 mg twice daily increased the Cmax and AUC of rifabutin by an average of 3- and 4-fold, respectively, compared to rifabutin given alone.

MANAGEMENT: The use of voriconazole with rifabutin is considered contraindicated.

Rifabutin

Generic Name: rifabutin

Brand name: Mycobutin

Synonyms: n.a.

What is Rifabutin?

Vfend

Generic Name: voriconazole

Brand name: Vfend, Vfend

Synonyms: Vfend Injection

What is Vfend?