Ritonavir Tablets and Zyprexa Zydis
Determining the interaction of Ritonavir Tablets and Zyprexa Zydis and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using ritonavir together with OLANZapine may decrease the effects of OLANZapine. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with ritonavir may significantly decrease the plasma concentrations of olanzapine. The mechanism is ritonavir induction of CYP450 1A2 and uridine 5' diphosphate glucuronosyltransferase, the enzymes responsible for the metabolic clearance of olanzapine. In 14 healthy, nonsmoking volunteers, ritonavir (300 mg titrated to 500 mg orally twice a day over 11 days) decreased the mean peak plasma concentration (Cmax), area under the concentration-time curve (AUC) and half-life of olanzapine (10 mg single oral dose) by 40%, 53% and 50%, respectively, compared to administration of olanzapine alone. Oral clearance increased by 115%. All but one subject reported less sedation with olanzapine after ritonavir administration than before.
MANAGEMENT: Patients treated concomitantly with ritonavir may require a higher dosage of olanzapine to control psychotic symptoms. Pharmacologic response to olanzapine should be monitored more closely whenever ritonavir is added to or withdrawn from therapy in patients stabilized on their antipsychotic regimen, and the olanzapine dosage adjusted as necessary.
- Penzak SR, Hon YY, Lawhorn WD, Shirley KL, Spratlin V, Jann MW "Influence of ritonavir on olanzapine pharmacokinetics in healthy volunteers." J Clin Psychopharmacol 22 (2002): 366-370
- "Product Information. Norvir (ritonavir)." Abbott Pharmaceutical, Abbott Park, IL.
Generic Name: ritonavir
Brand name: Norvir, Norvir Soft Gelatin
Synonyms: Ritonavir
Generic Name: olanzapine
Brand name: Zyprexa, Zyprexa Zydis, Zyprexa Intramuscular, Zyprexa Relprevv
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ritonavir Tablets-Zyrtec
- Ritonavir Tablets-Zyrtec (Cetirizine Capsules and Tablets)
- Ritonavir Tablets-Zyrtec (Cetirizine Chewable Tablets)
- Ritonavir Tablets-Zyrtec (Cetirizine Orally Disintegrating Tablets)
- Ritonavir Tablets-Zyrtec (Cetirizine Syrup)
- Ritonavir Tablets-Zyrtec Capsule
- Zyprexa Zydis-Rituxan
- Zyprexa Zydis-Rituxan Hycela
- Zyprexa Zydis-Rituximab
- Zyprexa Zydis-Rituximab and Hyaluronidase
- Zyprexa Zydis-Rituximab and hyaluronidase human, recombinant Subcutaneous
- Zyprexa Zydis-Rituximab Intravenous