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Serzone and Xanax

Determining the interaction of Serzone and Xanax and the possibility of their joint administration.

Check result:

Serzone <> Xanax

Relevance: 15.04.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using ALPRAZolam together with nefazodone may increase the effects of ALPRAZolam. Contact your doctor if you experience extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, and feeling light-headed. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSE: Nefazodone, when administered with alprazolam, has caused a two-fold increase its half-life, area under the plasma concentration-time curve, and peak plasma concentrations. The mechanism is inhibition of hepatic CYP450 3A4 metabolism by nefazodone.

MANAGEMENT: The manufacturer recommends a 50% reduction in the initial dosage of alprazolam. Patients receiving this combination should be monitored for excessive and prolonged sedation. Lorazepam, oxazepam, and temazepam undergo conjugative metabolism and may be suitable alternatives.

References

"Product Information. Serzone (nefazodone)." Bristol-Myers Squibb, Princeton, NJ.
Riesenman C "Antidepressant drug interactions and the cytochrome p450 system: a critical appraisal." Pharmacotherapy 15 (1995): s84-99
Kroboth PD, Mcauley JW, Derry CL "Time-dependent sensitization to triazolam? An observation in three studies." J Clin Psychopharmacol 15 (1995): 192-6
Barbhaiya RH, Shukla UA, Kroboth PD, Greene DS "Coadministration of nefazodone and benzodiazepines: 2. a pharmacokinetic interaction study with triazolam." J Clin Psychopharmacol 15 (1995): 320-6
Greene DS, Salazar DE, Dockens RC, Kroboth P, Barbhaiya RH "Coadministration of nefazodone and benzodiazepines: 3. a pharmacokinetic interaction study with alprazolam." J Clin Psychopharmacol 15 (1995): 399-408

Serzone

Generic Name: nefazodone

Brand name: Serzone

Synonyms: n.a.

What is Serzone?

Xanax

Generic Name: alprazolam

Brand name: Niravam, Xanax, Xanax XR, Alprazolam Intensol

Synonyms: n.a.

What is Xanax?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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